Etheridge earned her second Grammy for Best Rock Vocal Performance, Female for her single "Come to My Window.” She also garnered two additional nominations in the Best Rock Song category for "I'm the Only One" and "Come to My Window" losing to Bruce Springsteen's "Streets of Philadelphia.”
In a visit to Leavenworth in November 1994, she performed a benefit concert for a new park to be built near the high school. A ball field at the park is named after her father, John Etheridge. (In 1992, Etheridge established a performing arts scholarship at Leavenworth High School in honor of her father.)
The success of Yes I Am helped increase sales of Etheridge's earlier albums. In 1995 Melissa Etheridge earned a RIAA certification of 2× Platinum while Never Enough earned a RIAA certification of Platinum.
Then in 2010, Tammy and Melissa separated. At the time, Melissa’s rep said: "Melissa and Tammy Etheridge are saddened to announce that they are now separated. We ask for consideration and respect for our family as we go through this difficult period."